منابع مشابه
Pathogenesis of lupus.
This review highlights advances made over the past 2 years in understanding the pathogenesis of systemic lupus erythematosus (lupus). The criteria used in selecting the articles include: 1) the study was performed using human subjects as opposed to animal models; 2) the quality of methods, data, and interpretation were acceptable; and 3) a current body of literature exists supporting causality ...
متن کاملThe Pathogenesis of Lupus Nephritis
Lupus nephritis is a serious potential feature of systemic lupus erythematous (SLE). Though SLE typically cycles through periods of flares and remission, patients often eventually succumb to end-stage kidney or cardiovascular damage. This review of the pathogenesis of lupus nephritis examines the role of the complement cascade; the significance of autoantibodies, the breaking of tolerance, and ...
متن کاملThe pathogenesis of lupus nephritis.
Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE. The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The extrarenal etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear autoantigens. This loss of tolerance becomes clinica...
متن کاملPathogenesis of systemic lupus erythematosus.
The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved. Multiple genes contribute to disease susceptibility. The interaction of sex, hormonal milieu, and the hypothalamo-pituitary-adrenal axis modifies this susceptibility and the clinical express...
متن کاملAPOPTOSIS IN LUPUS PATHOGENESIS Eric
Apoptosis has been implicated in lupus pathogenesis in at least three different ways. As antigen, apoptotic material drives autoimmune responses. As immune modulator, impaired apoptosis makes patients susceptible to developing autoimmunity. As effector mechanism, apoptosis participates in target organ injury. This review summarizes the evidence that links apoptosis to these components of lupus ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2002
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.10380